A new platinum(II) complex containing ethylenediamine (En) and etidronate (Et) ligands was successfully synthesized and fully characterized. Etidronic acid (HEDP), also known as 1-hydroxyethylidene-1,1-diphosphonic acid, was first prepared and confirmed through a combination of spectroscopic analyses, including 31P NMR, 1H NMR, infrared (IR), and Raman spectroscopy. To enable its coordination to the platinum center, the free acid was neutralized with a stoichiometric amount of sodium hydroxide, yielding its disodium salt form, which exhibits higher solubility and stability in aqueous media. Subsequently, the desired complex [Pt(En)(Et)] was synthesized via a two-step substitution process: first, the chloride ligands in [Pt(En)Cl2] were replaced by nitrate ions under mild conditions, and then the nitrate groups were displaced by the etidronate ligand to yield the target bisphosphonate complex. The product was isolated as a stable, water-soluble solid, and its composition and coordination environment were confirmed by spectroscopic methods. The combination of both the ethylenediamine chelating agent and the etidronate ligand results in a coordination framework that enhances the chemical stability and water Solubility of the platinum center. These features make the synthesized complex a promising structural prototype for further exploration in medicinal and biomineral chemistry, especially in the development of platinum-based therapeutic and diagnostic agents. The unique combination of stability, solubility, and potential biological activity provides valuable insights into the design of new classes of bioactive platinum(II)-bisphosphonate compounds with improved functional properties.
Sadeghian, M. , Salehi, A. , Golbon Haghighi, M. and Bader, A. T. (2026). Water Soluble Platinum Complex Featuring a Chelating Bisphosphonate Ligands as Bioactive Compound. Pioneering Advances in Materials, 1(3), 1-6. doi: 10.48308/piadm.2025.242067.1012
MLA
Sadeghian, M. , , Salehi, A. , , Golbon Haghighi, M. , and Bader, A. T. . "Water Soluble Platinum Complex Featuring a Chelating Bisphosphonate Ligands as Bioactive Compound", Pioneering Advances in Materials, 1, 3, 2026, 1-6. doi: 10.48308/piadm.2025.242067.1012
HARVARD
Sadeghian, M., Salehi, A., Golbon Haghighi, M., Bader, A. T. (2026). 'Water Soluble Platinum Complex Featuring a Chelating Bisphosphonate Ligands as Bioactive Compound', Pioneering Advances in Materials, 1(3), pp. 1-6. doi: 10.48308/piadm.2025.242067.1012
CHICAGO
M. Sadeghian , A. Salehi , M. Golbon Haghighi and A. T. Bader, "Water Soluble Platinum Complex Featuring a Chelating Bisphosphonate Ligands as Bioactive Compound," Pioneering Advances in Materials, 1 3 (2026): 1-6, doi: 10.48308/piadm.2025.242067.1012
VANCOUVER
Sadeghian, M., Salehi, A., Golbon Haghighi, M., Bader, A. T. Water Soluble Platinum Complex Featuring a Chelating Bisphosphonate Ligands as Bioactive Compound. Pioneering Advances in Materials, 2026; 1(3): 1-6. doi: 10.48308/piadm.2025.242067.1012
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